[3] Bolstered by the signing of Freddie Freeman, the Dodgers became the first team to clinch a playoff spot on September 12, the 10th straight year they had made the postseason.

Despite the record, they were upset by the 89-win San Diego Padres in the NLDS, losing in four games, which meant that the Dodgers did not make it to the World Series despite 100 wins for the third time in four seasons.

Former Dodger Eric Karros, Dontrelle Willis, José Mota and Jessica Mendoza would be calling select road and home games as well as participating in the studio show.

[12] On March 18, outfielder Luke Raley was traded to the Tampa Bay Rays in exchange for minor league pitcher Tanner Dodson.

[15] On November 19, the Dodgers added five minor leaguers to the 40-man roster: Pitcher Michael Grove, infielders Jacob Amaya, Eddys Leonard, and Jorbit Vivas and outfielder James Outman.

The National League adopted the designated hitter full-time, a draft lottery was implemented, the postseason expanded from ten teams to twelve, and advertising patches appeared on player uniforms and helmets for the first time.

[54] Julio Urías allowed only one hit while striking out five in five scoreless innings on April 16 while Trea Turner's two run homer put the Dodgers on top and led to a 5–2 win.

[67] On April 30, Kershaw struck out Spencer Torkelson to move past Don Sutton to become the Dodgers all-time franchise strikeout leader.

[71] The Dodgers went back on the road to play the Chicago Cubs at Wrigley Field, beginning with a doubleheader on May 7 as a result of poor weather the previous day.

Ryan Pepiot made his MLB debut as the Dodgers starting pitcher, and was wild with five walks and a hit batter in three innings but did not allow a run.

Tyler Anderson struck out eight in eight scoreless innings and Freddie Freeman had three hits, including two doubles, as the Dodgers won 10–1 to start the series.

[100] In the next game, Walker Buehler had the shortest start of his career, recording only seven outs while allowing five runs to score as the Mets (thanks to two homers by Pete Alonso) won 9–4.

[105] Darin Ruf hit two home runs and Buehler was lost to an injury as the San Francisco Giants beat the Dodgers, 7–2, at Oracle Park.

[112] Andrew Heaney returned from a lengthy injured list stint to strikeout seven while allowing only one earned run in five innings but the Guardians rallied against the Dodgers bullpen and won 5–3.

They forgot to bring the bats and lost the opener, 4–0, managing only three hits against Rockies starter Chad Kuhl who threw a complete game shutout.

[133] The Dodgers traveled to play the St. Louis Cardinals at Busch Stadium and saw the seven game winning streak come to an end in a 7–6 loss, despite four hits (including a home run) by Freddie Freeman.

[135] The Dodgers took the final game of the series, 4–0, as Tyler Anderson pitched six scoreless innings, Gavin Lux homered and Freeman and Smith each had two hits, including a double.

[140] Anderson struck out six in six innings without allowing an earned run and Cody Bellinger hit the team's first grand slam of the season as the Dodgers took the next game, 5–1.

[141] In the third game, Urías pitched six scoreless innings and Betts, Trea Turner and Freeman all homered as the Dodgers continued their winning streak with a 4–2 victory.

[152] Julio Urías pitched six scoreless innings in the next game as the Dodgers shut out the Giants, 3–0, with two of the runs driven in by Miguel Vargas in his major league debut.

[157] Urías had another strong start on August 9 in the opener of a two-game series with the Minnesota Twins, striking out eight while only allowing one run in seven innings as the Dodgers won 10–3.

[164] Tony Gonsolin struck out eight while only allowing two hits in seven scoreless innings in the following game while Muncy and Austin Barnes homered to account for the Dodgers scoring in a 2–1 win.

[170] The Dodgers won the next game, 10–1, as Gonsolin picked up his 16th win of the season, Trea Turner and Freddie Freeman each had three hits and Trayce Thompson homered.

[171] In the last game of the series, Andrew Heaney struck out 10 in six innings, Austin Barnes homered and drove in four runs, and the Dodgers won 12–6.

[187] Justin Turner hit two home runs, including a grand slam, as the Dodgers won 11–2 on September 11 and clinched their 10th consecutive trip to the postseason.

[204] The Dodgers returned home to end the regular season with an unusual six-game series against the Colorado Rockies, that was made necessary by the need to make up games postponed because of the pre-season lockout.

Kershaw pitched six shutout innings, Cody Bellinger hit a three-run homer, and the Dodgers cruised to a 10–1 win that clinched the best record in all of MLB and homefield advantage throughout the playoffs.

[205] On October 1, the Dodgers rallied from three runs down to beat the Rockies 6–4 for their 110th win of the season, the first National League team to reach that mark since the 1909 Pittsburgh Pirates.

[209] In the final game of the regular season, Clayton Kershaw struck out nine in five innings and the Dodgers won 6–1 for their 111th win, the most in the majors since the 2001 Mariners and the most in the National League since the 1906 Cubs.

[213] In the fourth game, Tyler Anderson allowed only two hits in five scoreless innings and the Dodgers took a 3–0 lead on a two-run double by Freeman and a Will Smith sacrifice fly.