The 2022 Major League Baseball draft took place on July 17–19, 2022, in Los Angeles.

The Baltimore Orioles, who had the worst record of the 2021 season, selected Jackson Holliday with the first overall pick in the draft.

The New York Mets received the 11th pick as compensation for failing to sign Kumar Rocker.

[3] The Boston Red Sox received the 41st pick as compensation for failing to sign Jud Fabian.

[4] As a result of reaching the third surcharge tier of the competitive balance tax threshold in 2021, the Los Angeles Dodgers' top pick was moved down 10 slots.