Eastern teams faced their conference rivals in a double round-robin format, with one additional game.

[3] On June 3, 2022, MLR announced that the Austin Gilgronis were disqualified from the 2022 post-season, due to "violation of league rules".

[4] On June 7, 2022, MLR announced that the LA Giltinis were also disqualified from the 2022 post-season, again due to "violation of league rules".

This marked the successive year of Atlanta hosting New York in the Championship Series, having faced each other in the 2021 Eastern Conference Final.

The first half of the match was focused on defensive decisions, and forcing penalties, as the visitors led 9-6 at halftime.

Although Atlanta reduced the deficit with penalties, New York scored another try from the driving maul to effectively seal their victory.

Assistants: Federico Anselmi (UAR) & Jack Gohl (RA) TMO: Nick Hannon (USAR) Man of the Match: Dylan Fawsitt (Rugby New York) The Conference Final was hosted by the New England Free Jacks, at Veterans Memorial Stadium.

Assistants: Mike Lash (NZR) & Cisco Lopez (USAR) TMO: Nick Hannon (USAR) Man of the Match: Andrew Coe (Rugby New York) The Western Eliminator featured the Seattle Seawolves hosting the San Diego Legion at Starfire Stadium.