The Wolverines were led by eighth-year head coach Jim Harbaugh, and compiled an overall record of 12–0 (9–0 in the conference), winning the Big Ten East Division title for the second consecutive season.

On Michigan's second drive, quarterback Cade McNamara threw a bubble screen pass to Roman Wilson who caught the ball at the 36-yard line and ran 64 yards for the opening score.

Colorado State took the second-half kickoff, and on fourth down, quarterback Clay Millen fumbled, and Michigan defensive back D. J. Turner recovered the loose ball and returned it 45 yards for a touchdown.

On their opening possession, the Wolverines drove 66 yards in 36 seconds on a 24-yard run by Blake Corum and a 42-yard touchdown pass from McCarthy to Roman Wilson.

On Michigan's final possession of the half, Cade McNamara entered the game at quarterback and sustained an injury after being tackled behind the line of scrimmage.

On Michigan's first drive of the second half, McCarthy led the team 83 yards on 11 plays, including a 17-yard pass to Roman Wilson and Corum's fifth touchdown on an 11-yard run.

Late in the third and early in the fourth quarter, Michigan drove 84 yards in 10 plays, ending with a 20-yard touchdown pass from McCarthy to Roman Wilson.

Late in the first and early in the second quarter, Indiana drove 52 yards on 12 plays, tying the score on a 41-yard field goal by Charles Campbell.

[50][51][52] On the opening drive of the game, Michigan drove 64 yards to the Penn State 11-yard line, and Jake Moody kicked a 29-yard field goal.

After holding Penn State to a three-and-out, Michigan drove 77 yards on its second drive, including a 35-yard gain on a pass from J. J. McCarthy to Cornelius Johnson.

On Michigan's fourth possession, Curtis Jacobs intercepted a McCarthy pass and returned it 47 yards for Penn State's second touchdown in a span of less than two minutes.

On Michigan's first possession, the Wolverines drove 33 yards, but Cornelius Johnson fumbled and the loose ball was recovered for the Spartans by Dashaun Mallory.

Early in the second quarter, Michigan retook the lead with an 80-yard drive, ending with a two-yard touchdown pass from McCarthy to Blake Corum.

Chris Solari of the Detroit Free Press was present and reported that he saw Michigan State players punching, shoving and kicking McBurrows.

Green was struck by a helmet swung by a Michigan State player, reportedly sustained a concussion and facial cuts, and hired attorney Tom Mars to file a lawsuit for assault.

"[65] Bob Wojnowski of The Detroit News described it as a "brutal attack" and condemned the actions of the Michigan State players as "profound cowardice.

"[67] On the Sunday evening after the game, Tucker announced the suspension of four players: Angelo Grose, Zion Young, Itayvion "Tank" Brown, and Khary Crump.

[68] On November 1, Michigan State suspended four additional players: Malcolm Jones, Justin White, Jacoby Windmon and Brandon Wright.

[71] On December 24, a plea deal was announced and on January 5, 2023, Khary Crump will plead guilty to misdemeanor counts of assault/battery and disorderly conduct person-jostling.

[74][75][76] Early in the fourth quarter, Michigan drove 61 yards on eight run plays by Davis Warren, scoring on a 29-yard field goal by Jake Moody.

After a short 22-yard punt by Hugh Robertson, Michigan drove 24 yards to Illinois 28-yard line, and Jake Moody kicked a 46-yard field goal.

Illinois led, 17–10, at the end of the third quarter, marking the first time Michigan trailed in the second half of a game to that point in the season.

[89][90][91] Michigan extended its lead early in the fourth quarter on a three-yard touchdown run by McCarthy, culminating a 15-play, 81-yard drive that consumed 7:51 off the clock.

On the next play from scrimmage after the field goal, Donovan Edwards, wearing a cast on his right hand, scored on a 75-yard touchdown run down the right sideline with 7:11 remaining in the game.

[89][90][91] At the end of the game, Michigan defensive back Mike Sainristil planted a "Block M" flag in the "O" logo in the middle of the field.

McCarthy became the first quarterback in program history to begin his career with at least 11 wins as a starter before taking his first loss, surpassing the previous record of 10 set by Dennis Franklin in 1972.

[94][95] After holding Purdue to a three-and-out following the opening kickoff, Michigan drove 55 yards on seven plays, scoring on a 25-yard pass from J. J. McCarthy to Colston Loveland.

Michigan responded with a 13-play, 75-yard drive that included a fourth-down conversion on a two-yard run by Kalel Mullings and ended with a seven-yard touchdown pass from McCarthy to Luke Schoonmaker.

In the closing minutes of the game, Michigan recovered an on-side kick and drove 44 yards with Mullings scoring on a three-yard touchdown run.

TCU scored 10 points in the fourth quarter via a 76-yard touchdown pass from Duggan to Quentin Johnston and a 33-yard field goal by Griffin Kell.