The semifinals and finals took place at Betty & Bobby Allison South Stadium in Springfield, Missouri.
The seven-team single-elimination tournament consisted of three rounds based on seeding from regular season conference play.
The conference tournament title was the fourth, and third in a row for the Missouri State men's soccer program, and third for head coach Michael Seabolt.
All seven Missouri Valley Conference men's soccer programs qualified for the 2022 Tournament.
The teams drew 3–3 during their regular season match-up, so goal differential in league play was used as the second tiebreaker.