[9][10] The sponsoring organization's campaign manager said on May 4, 2022, that they were "confident" that the number of signatures collected by that date, a few days before the deadline, "provides the necessary cushion to qualify for the ballot".

[12] On August 9, 2022, The Missouri Secretary of State, Jay Ashcroft, certified the initiative to appear as Amendment 3 on the November ballot.

[13][14][15] In August 2022, on the last day of the 10-day challenge period following certification, the prohibitionist organization Protect Our Kids funded a lawsuit to remove the initiative from the November ballot.

[17] The Associated Press used the suit as an example of "pushback against the initiative process [that] is part of a several-year trend that gained steam as groups aligned with the Democratic Party have increasingly used petitions to force public votes on issues that Republican-led legislatures have opposed".

[19] In September 2022, lawmakers pushed to have cannabis added to a special session called by Governor Mike Parson, over disagreements with policies outlined in Amendment 3, particularly with licensing.