Kerry were defending champions and went on to retain the title after a 1–28 to 0–8 win against Limerick in the final on 28 May.

[3] Cork and Kerry, finalists from the 2021 championship, received a bye to the semi-finals.

Kerry (1st) Cork (2nd) Limerick (SF) Tipperary (SF) Clare (QF) Waterford (QF)

The lowest ranked counties to play in the quarter-finals were Tipperary and Waterford of Division 4.The two finalists from the 2021 championship entered this round along with the two quarter-final winners.

Kerry advanced to the 2022 All-Ireland Senior Football Championship quarter-finals, while Limerick advanced to the qualifiers.