The team who finished on top of the NBL1 Wildcard ladder, based on points percentage, were granted entry as the sixth women's and men's teams in the 2022 NBL1 National Finals alongside the State Conference champions.

[18][19] Stephanie Reid of the Townsville Flames was named women's grand final MVP while Jason Cadee of the Gold Coast Rollers was named men's grand final MVP.

[20][21] The women's grand final saw the West Adelaide Bearcats defeat the Sturt Sabres 82–75[22] while the men's grand final saw the South Adelaide Panthers defeat the Woodville Warriors 88–58.

[23] Madelynn Utti of the West Adelaide Bearcats was named women's grand final MVP while Alex Starling of the South Adelaide Panthers was named men's grand final MVP.

[29] Unique Thompson of the Albury Wodonga Bandits was named women's grand final MVP while Glenn Morison of the Canberra Gunners was named men's grand final MVP.

[9] The Southern Districts Spartans from the North Conference finished on top of the Wildcard women's ladder while the Frankston Blues from the South Conference finished on top of the Wildcard men's ladder.

[32] It served as the inaugural National Finals after the 2021 event was cancelled due to the COVID-19 pandemic.

[34] Both West Conference teams were victorious in the Championship Games, with the Warwick Senators women and the Rockingham Flames men becoming the inaugural NBL1 National champions.