The 2022 NCAA Division II women's basketball tournament was the single-elimination tournament to determine the national champion of women's NCAA Division II college basketball in the United States.

Glenville State won its first title by defeating Western Washington, 85–72.

[2] First, second, and third-round games, which comprise each regional championship, will take place on campus sites on March 11, 12, and 14.

These eight locations were chosen to host regional games for the 2022 tournament: The national quarterfinals, semifinals, and finals will be held on March 21, 23, and 25 at a pre-determined site, the Birmingham CrossPlex in Birmingham, Alabama.

The bids are allocated evenly among the eight NCAA-designated regions (Atlantic, Central, East, Midwest, South, South Central, Southeast, and West), each of which contains either two or three of the twenty-three Division II conferences that sponsor men's basketball (after the Heartland Conference disbanded in 2019, the South Region now features only two conferences).