The season began on December 3, 2021, and ended with the NLL final in late spring of 2022.
This was the inaugural season for the expansion team Panther City Lacrosse Club, and the Albany FireWolves who relocated from New England.
The NLL returned after missing a season due to the COVID-19 pandemic.
[4] The Colorado Mammoth defeated the Buffalo Bandits in a best of three series to win its first championship since 2006.
[6] Reference: [7] Note: GP = Games played; G = Goals; A = Assists; Pts = Points; PIM = Penalty minutes; LB = Loose Balls Note: GP = Games played; Mins = Minutes played; W = Wins; L = Losses: GA = Goals Allowed; SV% = Save Percentage; GAA = Goals against average *Overtime Bandits win series 2–0.