The lineup of teams remained unchanged for the 16th consecutive year.

[19] The pre-season also saw the first ever rugby league match to be played in the western Victorian city of Ballarat when Melbourne Storm played the Newcastle Knights at Eureka Stadium in front of 5,127 people.

[21] The match between the New Zealand Warriors and the Gold Coast Titans was cancelled after being initially postponed and rescheduled from Moreton Daily Stadium to Cbus Super Stadium due to the 2022 South East Queensland flood.

a^ The match was initially scheduled to be played on 26 February at Moreton Daily Stadium, but was rescheduled due to the 2022 South East Queensland flood.

[22] Bold – Home game X – Bye * – Golden point game Opponent for round listed above margin † Match decided in extra time.