The 2022 season of the Knock on Effect New South Wales Cup was the 115th season of the premier state rugby league competition in New South Wales.

The 2022 season of the Knock-On Effect New South Wales Cup commenced on the weekend of 12–13 March 2022.

Penrith Panthers won the 2022 NSW Cup Grand Final, defeating Canterbury-Bankstown Bulldogs 29–22 at CommBank Stadium to take their fourth premiership.

The website, League Unlimited, also maintain a Ladder for the NSW Cup.

As premiers of the NSW Cup, the Penrith Panthers faced Queensland Cup premiers Norths Devils in the NRL State Championship match.Soni Luke  28' Eddie Blacker  32' John Faiumu  45' Robert Jennings  47' Luke Sommerton  62' Sunia Turuva  79' Goals: Kurt Falls  9', 29', 34', 63', 72' (5/7) John Faiumu  80' (1/1) Tony Tumusa  64' Rashaun Denny  73' Goals: Connor Broadhurst  75' (1/2) [10]