The Cornhuskers were members of the Big Ten Conference and played their home games at Haymarket Park in Lincoln, Nebraska.

They were led by third-year head coach Will Bolt.

The Cornhuskers finished the 2021 NCAA Division I baseball season 31–12 overall (31–12 conference) and first place in conference standings, as the season was limited to only conference games for all Big Ten teams due to the COVID-19 pandemic.

For the 2022 Big Ten Conference poll, Nebraska was voted to finish in first by the Big Ten Coaches.

[2] Will Bolt Lance Harvell Danny Marcuzzo Jeff Christy Roster Last update: February 15, 2022 ^ Collegiate Baseball ranked 40 teams in their preseason poll, but only ranked 30 teams weekly during the season.† NCBWA ranks 35 teams in their preseason poll, but only ranks 30 teams weekly during the season.