The attack mainly occurred in a children's nursery located in the Uthai Sawan subdistrict of the Na Klang district.

[2][3] It is the deadliest mass murder by a single perpetrator in the modern history of Thailand, surpassing the death toll of the Nakhon Ratchasima shootings in 2020.

[4] On 6 October 2022, at around 11:24 ICT (UTC+7), the assailant, Panya Khamrab, drove a white pickup truck out of his residence.

[6] Armed with a 9mm pistol, a shotgun, and a knife,[7] Khamrab fatally shot a father and son at the Uthai Sawan Sub-district Administrative Organization,[8] near the nursery.

[5] Eleven people died – nine adults and two children – outside the nursery as Khamrab shot from his vehicle, according to police.

[23] The provincial police investigation unit commented that most of the fatalities were from the combined results of gunshot and knife wounds.

[6] Khamrab was a resident of Nong Bua Lamphu province and a former police sergeant in Na Wang district.

His career in the police force began in 2012 and he had previously worked in Bangkok before being assigned to his birthplace of Nong Bua Lamphu.

[30] An Isaan Record interview also presented bullying of the perpetrator's stepson at the nursery and shunning of his girlfriend by the locals as possible causes.

[24][30][36] Police lieutenant general Kitti Praphat arrived in Nong Bua Lamphu province to initiate a manhunt for Khamrab.

Police advised people living in the area of the attack to be cautious as Khamrab's whereabouts were unknown.

[31] Thailand's prime minister, Prayut Chan-o-cha ordered relevant agencies to help the wounded and open an investigation into the event.

[39] Daycare centres in the area were closed, while all government institutions were instructed to fly their flags at half-mast.

[24] On 10 October, Prayut ordered law enforcement agencies to tighten controls on gun ownership and crack down on drug use.