The 2022 O'Reilly Auto Parts 150 at Mid-Ohio was the 15th stock car race of the 2022 NASCAR Camping World Truck Series, and the first iteration of the event.

The race was held on Saturday, July 9, 2022, in Lexington, Ohio at Mid-Ohio Sports Car Course, a 2.400 miles (3.862 km) permanent road course.

After an exciting battle with 3 laps to go, Parker Kligerman, driving for Henderson Motorsports, held off Zane Smith for his third career NASCAR Camping World Truck Series win, and his first of the season.

[5] Mid-Ohio Sports Car Course is a road course auto racing facility located in Troy Township, Morrow County, Ohio, United States, just outside the village of Lexington.

Corey Heim, driving for Kyle Busch Motorsports, scored the pole for the race, after having the fastest time in Round 1, which was 1:57.500 seconds, and a speed of 69.181 mph (111.336 km/h).