They were led by second-year head coach Tim Albin and played their home games at Peden Stadium in Athens, Ohio.

[11][12][13][14] They opened conference play with an overtime loss to media preseason MAC East favorite Kent State where they surrendered 736 offensive yards to the Golden Flashes.

[29] In a home game against Buffalo for control of the MAC East, Rourke threw a school record tying 5 touchdown passes in an easy 45–24 win.

[35] With Rourke and Parker Navarro out for the season Ohio turned to CJ Harris at quarterback to wrap up the division against Bowling Green.

[40][25] In spite of missing the last three and a half games of the season Kurtis Rourke became Ohio's first winner of the Vern Smith Leadership Award for MAC Player of the Year which has been given out since 1982.

[49] [51] at Peden Stadium • Athens, OH Ohio recovered from an early deficit and then had to hold on to avoid surrendering a late 17 point lead in winning a shootout against Florida Atlantic.

[52] Quarterback Kurtis Rourke and freshman kicker Nathanial Vakos both earned MAC East Player of the Week awards.

[53] at Beaver Stadium, University Park, Pennsylvania Penn St jumped out to an early lead and pulled away in an easy 46–10 over the Bobcats.

[54] at Jack Trice Stadium • Ames, IA The Bobcat offense was shut down for the second straight week as 2022 Iowa State held them to a season low 233 yards in an easy victory for the Cyclones.

[55] at Peden Stadium • Athens, OH In another shootout win Kurtis Rourke passed for 537 yards which was the most in Bobcat History while earning his second MAC East Offensive Player of the Week award of the season.

[56] Fordham's Fotis Kokosioulis broke the Patriot League record for receiving yards in a game with 320 and was player of the week for the entire FCS.

Freshman running back Sieh Bangura earned his second straight MAC East Offensive Player of the Week and Nataniel Vakos earned his second special teams player of the week award of the season by converting on 4 field goals including a career long of 55 yards.

[64] at Yager Stadium • Oxford, OH Ohio maintained control of its own destiny in the MAC East with a win over Miami in the Battle of the Bricks.

The Bobcats held a 10–7 halftime lead after a 1-yard run touchdown by Sieh Bangura in the first quarter and a Nathanial Vakos field goal on the last play of the half.

Safety Alvin Floyd had an interception ad 12 tackles to earn MAC East Defensive player of the week.

[67] The Bobcats changed their air it out style of offense that was prolific most of the season with Rourke at the helm and played to Harris's strengths by keeping the ball on the ground with 54 total rushing attempts for 204 yards on the game.

The defense took advantage and continued their significant second half of the season turnaround in holding the Falcons to 279 yards and netting 3 interceptions and a fumble recovery.

[68] Linebacker Keye Thompson led the way with 11 tackles and won MAC East Defensive Player of the Week for the second time in 2022.

Tariq Drake set Ohio up to score again with an interception of McDonald that was returned to the Falcon 14 with 39 seconds left in the half.

[70] After the teams exchanged punts to open the half the Bobcats ate up most of what was left on the third quarter with a 15 play drive that ended in a Nathanial Vakos field goal.

[37] at Ford Field • Detroit, MI Toledo came in to the championship game with the #1 defense in the MAC and was able to shut down Ohio's offense.

An interception by quarterback Ohio's CJ Harris, playing for the injured MAC player of the Year, Kurtis Rourke, allowed Toledo to go into the half with a 10–7 lead on a field goal with 16 seconds remaining.

After Torrie Cox Jr. intercepted a Peasley pass the teams exchanged punts again before Ohio extended their lead to four on a second Nathanial Vakos field goal.

[75] Through December 30, 2022 Source:[76] Key: POS: Position, SOLO: Solo Tackles, AST: Assisted Tackles, TOT: Total Tackles, TFL: Tackles-for-loss, SACK: Quarterback Sacks, INT: Interceptions, BU: Passes Broken Up, PD: Passes Defended, QBH: Quarterback Hits, FR: Fumbles Recovered, FF: Forced Fumbles, BLK: Kicks or Punts Blocked, SAF: Safeties, TD : Touchdown Since July 14, 2021, the head coach of the Ohio Bobcats has been Tim Albin.