The Cowboys played their home games at O'Brate Stadium as a member of the Big 12 Conference.

They were led by head coach Josh Holliday, in his tenth season at Oklahoma State.

In the 2021 Big 12 Conference baseball tournament, the fourth-seeded Cowboys made a run to the finals where they fell to second-seeded TCU 7–10.

They earned an at-large bid into the 2021 NCAA Division I baseball tournament, where they were seeded second in the Tucson Regional.

To be announced The following players signed National Letter of Intents to play for Oklahoma State in 2022.