The 2022 Oklahoma State Cowboys football team represented Oklahoma State University as a member of the Big 12 Conference during the 2022 NCAA Division I FBS football season.

Led by 18th-year head coach Mike Gundy, the Cowboys played home games at Boone Pickens Stadium in Stillwater, Oklahoma.

The preseason poll was released on July 7, 2022.

[1] Listed in the order that they were released 2022 Preseason All-Big 12 teams Source:[16] Oklahoma State and the Big 12 announced the 2022 football schedule on December 1, 2021.

[17][18] Roster Last update: 10/15/22 at Boone Pickens Stadium • Stillwater, OK at Boone Pickens Stadium • Stillwater, OK at Boone Pickens Stadium • Stillwater, OK at McLane Stadium • Waco, TX at Boone Pickens Stadium • Stillwater, OK at Amon G. Carter Stadium • Fort Worth, TX at Boone Pickens Stadium • Stillwater, OK at Bill Snyder Family Stadium • Manhattan, KS at David Booth Kansas Memorial Stadium • Lawrence, KS at Boone Pickens Stadium • Stillwater, OK at Gaylord Family Oklahoma Memorial Stadium • Norman, OK at Boone Pickens Stadium • Stillwater, OK at Chase Field • Phoenix, AZ