The 2022 Ole Miss Rebels softball team represented the University of Mississippi in the 2022 NCAA Division I softball season.

The Rebels played their home games at the Ole Miss Softball Complex.

They were invited to the Tucson Regional where they finished 2–2.

Cloud State) Katie Rietkovich Browder (USC Beaufort)Ryker Chason (LSU) Roster Date m/dd is for last scheduled game of series.

Source: 2022 SEC softball game results, 2022 SEC softball schedule Updated for entire regular season.