Barbora Krejčíková defeated Iga Świątek in the final, 5–7, 7–6(7–4), 6–3 to win the singles tennis title at the 2022 Ostrava Open.

[1][2] It was Krejčíková's second WTA Tour title in back-to-back weeks, and she ended Świątek's streak of ten consecutive victories in WTA Tour finals.

This marked only Świątek's second career loss in a WTA Tour-level final, out of twelve played (the other being at the 2019 Ladies Open Lugano).

Anett Kontaveit was the defending champion,[3] but retired in the second round against Tereza Martincová.

The top four seeds received a bye into the second round.