On March 10, 2022, MLB and the MLBPA agreed to a new collective bargaining agreement, thus ending the lockout.

Additionally, shortstop Oneil Cruz recorded the fastest-hit ball in Statcast history with a 122.4 mph single in a 14–2 loss against the Atlanta Braves.

[4] As a result, the team owners voted unanimously to lockout the players stopping all free agency and trades.

The National League will adopt the designated hitter full-time, a draft lottery will be implemented, the postseason will expand from ten teams to twelve, and advertising patches will appear on player uniforms and helmets for the first time.

Note: G = Games played; AB = At bats; R = Runs; H = Hits; 2B = Doubles; 3B = Triples; HR = Home runs; RBI = Runs batted in; SB = Stolen bases; BB = Walks; K = Strikeouts; AVG = Batting average; OBP = On-base percentage; SLG = Slugging percentage; TB = Total bases Source[10] (through October 5, 2022) Players in bold are on the active roster.