[1] Magallanes were the champions, clinching their first Primera B title as well as promotion to Primera División on the final day of the regular season with a 2–0 win over Deportes Recoleta on 1 November 2022.
[3] The tournament was played by 17 teams, 14 returning from the previous season, two relegated from the 2021 Campeonato Nacional (Deportes Melipilla and Santiago Wanderers), and the 2021 Segunda División Profesional champions Deportes Recoleta.
The top team at the end of the 34 rounds was the champion and was promoted to the Campeonato Nacional for its 2023 season, while the next five teams played a play-off tournament (Liguilla) in which the league runners-up received a bye to the final.
[4] Deportes Puerto Montt won 3–1 on aggregate and advanced to the semi-final.
Deportes Copiapó won 5–0 on aggregate and were promoted to Primera División.