[1] This was the first time Worlds was in Mexico since 2000, when it was also held in San Luis Potosi.

Bolivian Conrrado Moscoso won Men's Singles for the first time by defeating American Rocky Carson in the final, 8-11, 11-7, 11-4, 11-8.

Moscoso is the first Bolivian (and first South American) to win Men's Singles at Worlds.

The final was a rematch of the Men's Singles final at the 2014 Racquetball World Championships, when Carson defeated Moscoso to win the 4th of his record 5 Men's Singles World Championships.

2022 was the first time Carson had lost in a Men's Singles final at Worlds.