On September 4, 2022, Myles Sanderson killed 11 and injured 18 people in a mass stabbing at 13 locations on the James Smith Cree Nation and in Weldon, Saskatchewan, Canada.

[4] Police quickly identified Myles and sought him and his brother Damien as suspects in the killing spree.

[12] The brothers then picked up another woman, went to a bar in nearby Kinistino, and later returned to James Smith Cree Nation to sell cocaine again.

[13] At 4:03 a.m. CST on September 3, the Royal Canadian Mounted Police (RCMP) received a call from Damien's wife, saying her husband had stolen a vehicle on the First Nation and might be impaired.

Damien went to another Kinistino bar and told a woman that he and his brother had "a mission" and that "people would hear all about it in the next few hours.

[10] At 7:12,[17][18] the RCMP issued an emergency alert within the immediate region, identifying Myles and Damien as suspects and advising residents to stay in secure locations and to use caution when allowing others into their homes.

[17][19] At the request of the Saskatchewan RCMP, the civil emergency was later expanded to the entirety of the neighbouring provinces Alberta and Manitoba.

[19] The Saskatchewan Health Authority initiated a code orange, briefly issuing additional staff in hospitals local to the stabbings to help with the influx of patients.

[10] An emergency alert was issued by the RCMP at 2:49, warning that a man armed with a knife was last seen in Wakaw, had stolen a white Chevrolet Avalanche, and was believed to be related to the attacks.

The stolen truck was spotted at 3:17 by the driver of an unmarked police vehicle driving westbound on Highway 11 towards Rosthern, and a PIT manoeuvre was used to direct it into a ditch.

[28][29][21][30] They were believed to be driving a black Nissan Rogue,[31] and were reportedly seen in Melfort and the Arcola Avenue area of Regina.

He had been given statutory release in August 2021 after serving a five-year sentence for assault, robbery, mischief, and making threats.

[23] The attacks occurred hours before the scheduled CFL football game between the Saskatchewan Roughriders and the Winnipeg Blue Bombers in Regina, part of the popular Labour Day Classic.

[17] Queen Elizabeth II, in what would be her final public statement before her death the following day,[34] said that she "mourn[s] with all Canadians at this tragic time".

[35] The premier of Saskatchewan, Scott Moe, said, "There are no words to adequately describe the pain and loss caused by this senseless violence."

Prime Minister Justin Trudeau called the stabbings "horrific and heartbreaking", and said he was "thinking of those who have lost a loved one and of those who were injured".

Premier Moe announced that all flags at provincial government buildings would be lowered to half-mast for ten days in honour of the dead.

[26] It was suggested by analysts that the RCMP's extensive use of emergency alerts as part of public communications regarding the manhunt was a contrast and response to the 2020 Nova Scotia attacks[36] where the RCMP had relied almost exclusively on social media to post information regarding the suspect, and were unable to agree on an alert before the suspect was ultimately located and shot by police.

They called for federal parole board reforms, greater "autonomy for communities like theirs, including tribal police and the ability for bands to issue resolutions that could ban members from a community", as well as increased support for mental health and addictions treatment programs.

[40] Darryl Burns said that the plight of remote First Nation communities like theirs would only receive media attention for a two-week interval after the tragedy, so it was important to articulate their concerns during that window of time.