The election was conducted by the Electoral Commission of South Australia (ECSA), an independent body answerable to Parliament.

[15] In February 2021, Fraser Ellis, the Liberal member for Narungga, was charged by the Independent Commissioner Against Corruption (ICAC) with 23 counts of deception, relating to 78 fraudulent claims over the alleged misuse of a travel allowance totalling more than $18,000.

[16] Later that year, Dan Cregan, the Liberal member for Kavel, resigned from the party to sit as an independent, citing the government's failure to manage population growth in the Adelaide Hills.

Labor campaigned extensively on improving the state's healthcare infrastructure by 'fixing the ramping crisis', pledging to increase the amount of ambulances, hospital beds, nurses and doctors in order to combat long-standing overcrowding of hospitals and ramping of ambulances.

[26] As part of an effort to secure the electoral district of Kavel, Labor also promised to build a new hospital in Mount Barker.

[27] The Australian Christian Lobby campaigned for SA election candidates who opposed late-term abortions and who promote more socially conservative policies.

[41] As it was interpreted from 1991 to 2016, the Electoral Districts Boundaries Commission (EDBC) drew boundaries to try and ensure that the party winning the majority of the state-wide two-party preferred vote would also win a majority of the seats in the House of Assembly;[42] however, the Weatherill government repealed the fairness provision in 2017 so that it was no longer the second criteria for redistributions after equality.

The EDBC ruled that it could still consider fairness under a general provision that permits the Commission to "have regard to any other matters it thinks relevant".

The net change proposed retained a 27 Liberal−20 Labor notional seat count on a TPP basis when not considering elected independents.

[46] The pendulum below shows the post-redistribution margins, in percentage points, calculated by ABC’s Antony Green,[47] taking into account seats held by independents who are contesting their current seats at the next election, which differ somewhat to the margins calculated by the South Australian Electoral Districts Boundaries Commission that does not take into account currently elected independents.

Antony Green's margin estimates are more accurately calculated using declaration votes from the redistributed polling booths.

The Electoral (Miscellaneous) Amendment Act 2013 introduced set dates for writs for general elections in South Australia.

Additionally, the Liberals suffered large swings in previously safe seats such as Bragg, Morphett, and Hammond.

On 20 March 2022, Marshall announced he would resign as leader of the Liberals at a later date, but intended to remain the member for Dunstan.

[59][60] On 21 March 2022 Malinauskas was formally sworn as Premier by the Governor of South Australia, with Susan Close as his deputy.

[61][62] In April 2022, it was "formally confirmed" that a One Nation member won a seat within the South Australia legislative council (upper house) for the first time in history.