The 2022 Texas A&M–Commerce Lions football team represented Texas A&M University–Commerce as a member of the Southland Conference during the 2022 NCAA Division I FCS football season.

The Lions played their home games at Memorial Stadium in Commerce, Texas.

This was the program's inaugural season in the Southland Conference.

[1][2][3] The Southland Conference released their preseason poll on July 20, 2022.

The Lions were picked to finish sixth in the conference.