[6] The Argonauts had the sixth selection in each of the eight rounds of the draft after losing the East Final and finishing third in the 2021 league standings.

[7] The team also acquired another second-round pick after trading Nick Arbuckle to the Edmonton Elks.

[8] The Argonauts played their home preseason game at Alumni Stadium in Guelph, Ontario.

[1] [9][10][11] The Argonauts were the home team for a neutral site game for the Week 6 match-up with the Saskatchewan Roughriders.

[12] It was confirmed on March 24, 2022, that the game would be played in Wolfville, Nova Scotia at Raymond Field as part of the Touchdown Atlantic series.