It was first identified on Saturday, 20 August 2022, when 7 people arrived at the Tucumán Hospital with fever, malaise, shortness of breath, and headache.

[6][7]Influenza, COVID-19, Coxiella, 12 respiratory viruses, hantavirus, histoplasma, Yersinia pestis, and leptospirosis were ruled out through laboratory testing.

[1][8] On 5 September, the Ministry of Public Health of Tucumán reported new inclusion criteria for the case definition of the outbreak.

The new case definition included any health personnel, family, or patient who had been in or received surgery in this private health facility in the month of August, with compatible symptoms such as respiratory symptoms or fever, but not necessarily bilateral pneumonia.

[9] On 6 September, the Ministry of Public Health reported a total of 22 cases and six deaths.