The competition began with Strade Bianche on 5 March, and finished with the final stage of the Tour de Romandie Féminin on 9 October.
She won four overall victories during the season, including the Giro Donne and the inaugural Tour de France Femmes - becoming the first woman to complete a Giro–Tour double in the same year.
As in previous years, the teams classification was won by SD Worx - their sixth win in seven seasons.
In September 2021, the Tour de Romandie Féminin was added to make a total of twenty-five races.
[4][5] Due to COVID-19-related logistical concerns raised by teams regarding travel to Australia (including strict quarantine requirements), the Cadel Evans Great Ocean Road Race was cancelled.