Carlos Alcaraz defeated Casper Ruud in the final, 6–4, 2–6, 7–6(7–1), 6–3 to win the men's singles tennis title at the 2022 US Open.

1 singles ranking with the win;[1] Ruud, Rafael Nadal, Daniil Medvedev, and Stefanos Tsitsipas were also in contention for the top position.

[4][5] At 23 hours and 39 minutes of play duration across his seven matches, Alcaraz spent the longest time on court in major history (a record later broken by Medvedev at the 2024 Australian Open).

[8] Medvedev was the first man outside the Big Four to be the top seed at a major since Andy Roddick at the 2004 Australian Open.

Three-time champion Djokovic withdrew prior to the tournament as he could not travel to the United States, due to not having complied with the federal government's vaccination policy for non-US citizens against COVID-19.

Source:[21] The entry list was released by the United States Tennis Association based on the ATP rankings for the week of July 18.