Iga Świątek defeated Ons Jabeur in the final, 6–2, 7–6(7–5) to win the women's singles tennis title at the 2022 US Open.

Świątek was the first player since Angelique Kerber in 2016 to win multiple majors in a season, having also won the 2022 French Open.

[7] With her victory over second-ranked Anett Kontaveit in the second round, Williams became the oldest player to defeat a top-three opponent on the WTA Tour.

This tournament marked the first time in the Open Era that four Chinese women reached the third round of a major.

[10] Karolína Plíšková defeated Magda Linette in the first round in the first women's singles main-draw 10-point tie-break at the US Open.

Source:[12] The entry list was released by the United States Tennis Association based on the WTA rankings for the week of July 18.