Regularly scheduled elections were held for 34 of the 100 seats in the U.S. Senate, the winners of which will serve 6-year terms beginning with the 118th United States Congress.

[10][f] The better-than-expected performance of Democrats has been attributed to several factors,[11] including the issue of abortion after Dobbs v. Jackson Women's Health Organization,[12] the role of Donald Trump, and alleged extremism or election denialism among Republicans.

[13][14][15] The 2022 election cycle was the first time in U.S. history in which multiple Senate races in the same year were contested between two Black nominees (Georgia and South Carolina).

[22] Democrats' strong performance has been attributed to, among other factors,[11] backlash to abortion-rights restrictions following the U.S. Supreme Court's June 2022 decision in Dobbs v. Jackson Women's Health Organization that overturned Roe v. Wade,[12] negative reaction to Republican extremism and election denialism,[14][15] better candidate quality among Democrats than Republicans,[13] and youth turnout and vote splitting in key races.

[23][24] Some Republicans blamed Trump for the party's underwhelming showing, citing the underperformance of candidates he endorsed such as Herschel Walker in Georgia and Oz in Pennsylvania.

[10][f] Maggie Hassan (New Hampshire), Ron Johnson (Wisconsin), Mark Kelly (Arizona), Catherine Cortez-Masto (Nevada), Lisa Murkowski (Alaska), and Warnock (Georgia) faced competitive races but were all re-elected.

[63] Katie Britt, Shelby's former chief of staff,[64] and Mo Brooks, a six-term U.S. representative, finished ahead of businesswoman Karla DuPriest, former Army pilot and author Michael Durant, and author Jake Schafer in the first round of the Republican primary election, with Britt going on to defeat Brooks in a runoff.

In the Republican primary, Blake Masters, the chairman of the Thiel Foundation, defeated Jim Lamon, chair of the solar power company Depcom,[78] and Arizona Attorney General Mark Brnovich.

[82] Boozman defeated former NFL player and U.S. Army veteran Jake Bequette,[83] gun range owner and 2018 gubernatorial candidate Jan Morgan,[84] and pastor Heath Loftis[85] in the Republican primary.

[86] A fourth challenger, corporate analyst Michael Deel withdrew prior to the primary election citing a lack of viability.

[87] Natalie James, a real estate broker from Little Rock,[88] defeated Dan Whitfield, who attempted to run as an independent for Arkansas' other U.S. Senate seat in 2020 but failed to meet the ballot access requirements,[89] and former Pine Bluff City alderman Jack Foster in the Democratic primary.

He was appointed by Governor Gavin Newsom following the resignation of incumbent Democrat Kamala Harris on January 18, 2021, in advance of her swearing-in as Vice President of the United States.

Former state House minority leader Themis Klarides ran for the Republican nomination,[101] but lost to commodities trader Leora Levy.

[113] Former NFL player Herschel Walker,[114] who had been endorsed by former president Donald Trump,[115] defeated banking executive Latham Saddler[116] and others in the Republican primary.

[154] Despite previously indicating that he had no interest in pursuing the Republican nomination for the U.S. Senate, incumbent governor Larry Hogan, who was term-limited and scheduled to leave office in 2023, told conservative talk radio host Hugh Hewitt in October 2021 that he was considering challenging Van Hollen.

[174] U.S. Army brigadier general Don Bolduc narrowly defeated state senator Chuck Morse, former Londonderry town manager Kevin Smith, and others in the Republican primary.

[180] Despite Democrats overperforming expectations on a national level during this cycle, this race was the most competitive in Schumer's Senate career since his first election in 1998, when he won by 10.5%.

[183][184][185][186] U.S. representative Ted Budd, who was endorsed by former president Donald Trump, easily defeated former governor Pat McCrory in the Republican primary.

[187][188][185] Former chief justice of the state Supreme Court Cheri Beasley[189] easily defeated Beaufort mayor Rett Newton[190] in the Democratic primary.

[194][195] University of Jamestown engineering professor Katrina Christiansen defeated businessman Michael Steele in the Democratic primary election.

[61] Venture capitalist and author JD Vance was nominated in a crowded and competitive Republican primary, defeating USMCR veteran and former state treasurer Josh Mandel, state senator Matt Dolan, investment banker Mike Gibbons, and former Ohio Republican Party chair Jane Timken, among others.

[204][205] Jackson Lahmeyer, the pastor for Sheridan Church and former Oklahoma State coordinator for the Billy Graham Evangelistic Association, challenged Lankford in the Republican primary.

[213][214] Markwayne Mullin, a member of the Cherokee Nation, became the first Native American to serve in the U.S. Senate since fellow Republican Ben Nighthorse Campbell retired from Congress in 2005.

This is the first victory of Wyden's since 1996 where none of the following counties went Democratic in a Senate Class III election: Gilliam, Jackson, Marion, Polk, Wasco and Yamhill.

[223] Mehmet Oz, host of The Dr. Oz Show and cardiothoracic surgeon,[224] narrowly defeated business executive Dave McCormick, 2018 U.S. Senate candidate Jeff Bartos,[225] 2018 candidate for Pennsylvania's 7th congressional district Sean Gale,[226] political commentator Kathy Barnette,[227] and former U.S. ambassador to Denmark Carla Sands,[228] after a bitter Republican primary.

[231] In the Democratic primary, state representative Krystle Matthews defeated author and activist Catherine Fleming Bruce[232] in a runoff.

[241] Thune had been subject to some backlash from former president Trump and his supporters in the state of South Dakota, leading to speculation of a potential primary challenge.

[243] The Democratic candidate was author, navy veteran, and assistant professor of criminal justice at Northern State University, Brian Bengs, who won the primary unopposed.

[251] Former military officer Gerald Malloy was the Republican nominee, having narrowly defeated former United States attorney for the District of Vermont Christina Nolan in the primary.

[252] Republican nurse Tiffany Smiley also ran for the Senate seat,[254] and advanced to the general election after coming in second in the blanket primary with 33.7% of the vote.