[1] Metropolitanos won their first title in the competition, beating Monagas on penalty kicks after drawing 1–1 after extra time in the final.
On 6 October 2021, the Liga FUTVE initially announced the return of the Apertura and Clausura format for the 2022 season, with the top eight clubs advancing to a play-off stage in which international berths would be decided.
[3] The competition format was eventually confirmed by the Liga FUTVE on 12 January 2022 after a meeting with representatives from the 16 participating clubs.
[1] On 30 December 2021, the Venezuelan Football Federation announced the results of the club licensing process for the 2022 season.
Atlético Venezuela and Gran Valencia had their license applications denied, as well as the 2021 Segunda División champions Titanes, and were unable to take part in the competition.