Borna Ćorić defeated Stefanos Tsitsipas in the final, 7–6(7–0), 6–2 to win the men's singles tennis title at the 2022 Cincinnati Masters.

Alexander Zverev was the reigning champion,[2][3] but did not participate due to a long-term ankle injury.

[4] Medvedev retained the top ranking after Nadal lost in the second round to Ćorić.

Points for the 2021 tournament were not mandatory and are included in the table below only if they counted towards the player's ranking as of August 15, 2022.

† This column shows either the player's points from the 2021 tournament or his 19th best result (shown in brackets).