Elena Rybakina defeated Ons Jabeur in the final, 3–6, 6–2, 6–2 to win the ladies' singles tennis title at the 2022 Wimbledon Championships.

Ashleigh Barty was the reigning champion, but she retired from professional tennis in March 2022.

1 Iga Świątek's win streak of 37 matches (dating back to Qatar in February) ended when she was defeated by Alizé Cornet in the third round.

It was just the fourth loss of Świątek's season; her 37-match winning streak is the longest of the 21st century, and tied for 12th-longest in the Open Era.

[5] By making her 62nd consecutive major main draw appearance, Cornet tied Ai Sugiyama's all-time record.

[8] Williams received a wild card to play in the tournament, making her comeback to the sport after a year away due to a right hamstring injury;[9] she was defeated in the first round by Harmony Tan.

The WTA decided not to award ranking points for the 2022 tournament in response to the All England Club's decision to ban Russian and Belarusian players from participating.