The mixed 4 × 400 metres relay at the 2022 World Athletics Championships was held at the Hayward Field in Eugene, Oregon, United States, on 15 July 2022.

[1] Before the championships, the world record of 3:09.34 min was set by the relay team of the United States in 2019.

[2] The standard to qualify automatically for entry was to finish in the first 12 at 2021 World Relays, completed by 4 top lists' teams.

[3] The two heats of the first round were held on 15 July, starting at 11:45 (UTC−7) in the morning.

[4] The final was held on 15 July, starting at 19:50 (UTC−7) in the evening.