The women's 400 metres at the 2022 World Athletics Indoor Championships took place on 18 and 19 March 2022.

[1] Shaunae Miller-Uibo entered these championships with no other races this season, but as the two time Olympic gold medalist, her credentials preceded her.

Running two turns in lanes before breaking, Miller-Uibo reached the cones with the slightest of a margin ahead of Femke Bol, the #3 400 metres hurdler of all time outdoors.

As the athletes collapsed to lane 1, Miller-Uibo's long strides put her solidly into the lead ahead of Bol, as the rest of the competitors fell into line behind them.

Stephenie Ann McPherson made a run at Bol on the final straight out couldn't catch her.