The men's 100 metres at the 2022 World Athletics U20 Championships was held at the Estadio Olímpico Pascual Guerrero in Cali, Colombia on 1 and 2 August 2022.

[1] Originally, 78 athletes from 51 countries entered to the competition,[2][3] however, only 63 of them participated.

U20 standing records prior to the 2022 World Athletics U20 Championships were as follows:[4] *Mark pending ratification Round 1 took place on 1 August, with the 63 athletes involved being split into 8 heats, 7 heats of 8 and 1 of 7 athletes.

[5] The first 2 athletes in each heat ( Q ) and the next 8 fastest ( q ) qualified to the semi-final.

[8] The first 2 athletes in each heat ( Q ) and the next 2 fastest ( q ) qualified to the final.