The men's 4 × 100 metres relay at the 2022 World Athletics U20 Championships was held at the Estadio Olímpico Pascual Guerrero in Cali, Colombia on 4 and 5 August 2022.

[1] 25 national teams entered to the competition,[2][3] with each team having a minimum of 4 and maximum of 6 athletes.

[4] U20 standing records prior to the 2022 World Athletics U20 Championships were as follows:[5] The 25 national teams entered a total of 136 athletes,[2] Each team selected 4 athletes from their list in each round, however, the team selected for the round 1 could be made up of athletes entered by the nation in other events.

[6] The first team in each heat ( Q ) and the next 4 fastest ( q ) qualified to the final.

[7] The overall results were as follows:[8] The final (originally set for 18:00) was started at 19:09 on 5 August.