The women's 100m freestyle events at the 2022 World Para Swimming Championships were held at the Penteada Olympic Swimming Complex in Madeira between 12 and 18 June.
The final was held on 13 June 2022.
8 swimmers from 7 nations took part.
[1] 11 swimmers from 11 nations took part.
The swimmers with the top eight times, regardless of heat, advanced to the final.