The women's 400m freestyle events at the 2022 World Para Swimming Championships were held at the Penteada Olympic Swimming Complex in Madeira between 12 and 18 June.
7 swimmers from six nations took part.
[1] 11 swimmers from ten nations took part.
The swimmers with the top eight times, regardless of heat, advanced to the final.
[2] The final was held on 12 June 2022.