The 2022 WTA Slovenia Open (also known as the Zavarovalnica Sava Portorož for sponsorship purposes) is a WTA 250 tournament play on outdoor hard courts.

The 2022 event took place at the Tennis Club Portorož in Portorož, Slovenia from 12 to 18 September 2022.

[1] The event was held on the second consecutive year in the alternative sporting calendar, however, it was one of the six tournaments that were given single-year WTA 250 licenses in September and October 2022 due to the cancellation of tournaments in China during the 2022 season because of the ongoing COVID-19 pandemic, as well as the suspension of tournaments in China following former WTA player Peng Shuai's allegation of sexual assault against a Chinese government official.

[2][3] This was Siniaková's third WTA Tour singles title, and her first since 2017.

The following players received wildcard entry into the singles main draw: The following player received entry into the singles main draw with a special ranking: The following players received entry from the qualifying draw: The following player received entry as a lucky loser: The following pairs received wildcards into the doubles main draw: The following pair received entry as alternates: