The Tigers were led by 14th-year head coach Brad Brownell and played their home games at Littlejohn Coliseum in Clemson, South Carolina as members of the Atlantic Coast Conference.

They continued their strong start to the season, upsetting twenty-third ranked Alabama in the ACC–SEC Challenge.

A loss to Miami (FL) and eigtht-ranked North Carolina dropped them to twenty-first in the rankings.

Despite defeating Boston College and losing to Virginia Tech, the Tigers fell out of the rankings.

They Tigers won four of their last six games including the completion of a season sweep against Pittsburgh and Florida State.

They earned an at-large bid to the NCAA tournament and were placed as the sixth-seed in the West region.

[3] The Tigers would set another program record on February 15, 2023, when they defeated Florida State 94–54 at home.

This was the Tigers' widest margin of victory in ACC play, beating the previous record of a 34-point win in 1975.