They were led by third-year head coach Tony Stubblefield for the first 18 games of the season.

They played their home games at Wintrust Arena in Chicago, Illinois, as members of the Big East Conference.

On January 22, 2024, the school fired head coach Tony Stubblefield after starting the season 3–15.

They defeated Seton Hall in the first round of the Big East tournament before losing to Xavier in the quarterfinals.

On January 10, 2023, DePaul defeated Villanova for the first time since 2008, snapping a 22-game losing streak to the Wildcats.