The team played their home games at the Fertitta Center as first-year members of the Big 12 Conference.

In the Big 12 tournament, Houston defeated TCU and Texas Tech before losing to Iowa State in the championship game.

There they were defeated by Duke after losing their starting point guard, Jamal Shead, to an ankle sprain during the game.

They defeated East Carolina and Cincinnati to advance to the AAC tournament championship game where they lost to Memphis.

On November 28, 2022, the team reached the number one ranking in the AP Poll, marking the first time they had held the top spot since 1983.