Betis were eliminated from the Copa del Rey by Alavés in the round of 32 and exited the Europa League in the group stage after ranking third; after dropping down to the Europa Conference League, they were eliminated at the first attempt by Dinamo Zagreb, in the knockout round play-offs.

This season was the first since 2014–15 without veteran midfielder Joaquín, who annonounced his retirement following the previous campaign's conclusion.

Note: Flags indicate national team as defined under FIFA eligibility rules; some limited exceptions apply.

Note: Flags indicate national team as defined under FIFA eligibility rules; some limited exceptions apply.

Note: Flags indicate national team as defined under FIFA eligibility rules; some limited exceptions apply.