[4] On 12 August, Las Palmas played their first La Liga game since the 2017–18 season, being held 1–1 against Mallorca in their opening league match at Estadio Gran Canaria.

[5] On 17 August, Las Palmas announced the signing of Sory Kaba for an initial fee of €1,500,000 with additional payments of another €1,500,000 to be paid to FC Midtjylland.

[10] On 25 August, Las Palmas played their second home match of the season in a goalless draw against Real Sociedad with Enzo Loiodice hitting the crossbar twice during the game.

[14] On 17 September 2023, Las Palmas fell to a second consecutive loss to Sevilla after succumbing to a 1–0 result at the Ramón Sánchez Pizjuán Stadium.

Eric Curbelo made his First Division debut for the club, and Daley Sinkgraven returned to the starting line-up from injury.

A goal each from set pieces by Saúl Coco and Marc Cardona, who scored in his second consecutive game, earned the win for Las Palmas.

[22] On 22 October 2023, Las Palmas fell to their first defeat at home after losing 1–0 to Rayo Vallecano, following a late penalty goal by Bebé.

Aarón Escandell made his debut while Julián Araujo, Alberto Moleiro and Pau Ferrer scored a goal each to seal the match.