Iran doubled their lead ten minutes later after Ghoddos delivered a set-piece which Shojae Khalilzadeh quickly got on the end of to strike the ball into the net.
In the 38th minute, a failed clearance from Palestine's Mohammed Rashid was intercepted by Ansarifard, who then passed to Alireza Jahanbakhsh and then Ghayedi, striking a low shot to give Iran a three-goal lead.
In the sixth minute of first half stoppage time, a clever set-piece from Palestine's Zaid Qunbar caught Iranian defender Saeid Ezatolahi by surprise, as he headed the ball directly to his opponent Tamer Seyam, whose subsequent converted header was thus onside and reduced Iran's lead back to a two-goal margin.
The UAE had the better start, and in the 23rd minute, from a contested ball in the midfield won by Ali Saleh, he provided a perfect cross for Sultan Adil, who then headed into the Palestinian net to give the Emiratis the lead.
However, the match changed direction significantly after a pulling foul in the area from Emirati defender Khalifa Al Hammadi on Oday Dabbagh in the 34th minute, which resulted in Al Hammadi's dismissal after VAR intervention; despite this, Tamer Seyam failed to convert from the resulting penalty with goalkeeper Khalid Eisa keeping his effort out.
Nonetheless, Palestine's persistent pressure paid off in the 50th minute when, from a long-range delivery, Seyam redeemed himself with a tricky cross into the penalty area, which Bader Nasser's header turned into an own goal to level the match.
Iran had two more goals ruled out by VAR, first for an offside from Azmoun and then a second from Mohammad Mohebi due to his earlier foul on Emirati midfielder Majid Rashid.
This was Palestine's first-ever victory in Asian Cup history, and with four points, they managed to advance past the group stage for the first time ever.