The group stage draw took place on 19 April 2022 at 19:30 SAST (UTC+2) at SuperSport Broadcasting Studios in Johannesburg, South Africa.

The 48 national teams had previously been seeded into four pots of twelve each based on the March 2022 FIFA World Rankings (shown in parentheses).

The Ivory Coast matches and results counted in determining the qualification of the other teams from their group.

[6] Kenya and Zimbabwe were included in the draw despite being temporarily suspended by FIFA from all international football activities.

The draw ceremony was conducted by the CAF Director of Competitions Samson Adamu, with assistance by former South Africa defender Lucas Radebe and former Ivory Coast striker Salomon Kalou.