The Baltimore Orioles (101–61) clinched their first postseason berth since 2016 on September 17,[1] the American League East division title for the first time since 2014, a first-round bye, and the top seed in the AL on September 28 with a 100th win against the Boston Red Sox in a 2–0 shutout, giving them home-field advantage throughout the AL playoff.

The match-up was the two teams' second postseason meeting after the 2012 American League Wild Card Game, which Baltimore won.

In the top of the fifth inning, Mitch Garver ground into a double play, scoring Leody Taveras, and extending the lead to 10–4.

In the bottom of the same inning, Aaron Hicks hit a three-run home run, to make the final score 11–8 and giving the Rangers a chance for the sweep Tuesday night.

In the top of the fifth, the Orioles got on the scoreboard when Gunnar Henderson singled to right to score Jordan Westburg and cut the Rangers lead to 6–1.

In the bottom of the first inning, Jose Altuve homered off Ober on the first pitch to give the Astros a 1–0 lead, his Major League record eighth career leadoff home run in the postseason and 24th overall.

Verlander threw six shutout innings to post the sixth scoreless start of his postseason career, tying Madison Bumgarner and Tom Glavine for the most all-time.

[21] In the top of the seventh, Jorge Polanco hit a three-run home run off Hector Neris, followed shortly by a solo shot by Royce Lewis to narrow the Twins deficit to 5–4.

Later, in the bottom of the inning, Alvarez hit his second home run of the game off of Caleb Thielbar to extend the Astros lead to 6–4.

Bryan Abreu and Ryan Pressly combined for 21⁄3 scoreless innings to end the game and give the Astros their 12th straight ALDS win at home.

In the top of the first inning, Carlos Correa doubled, scoring Jorge Polanco to give the Twins the first run of the game.

Correa plated two more runs in the fifth with a single, allowing Michael A. Taylor and Donovan Solano to score, extending the lead to 5–0.

The Astros struck early off Gray, putting up four runs in the top of the first, punctuated by a José Abreu three-run homer.

Alex Bregman added to the lead in the fifth inning with a solo shot, marking the first time since September 24, 2021 that Gray had given up multiple home runs in a game.

Edouard Julien shortened the gap in the bottom of the sixth with a solo shot to bring the Twins within one, but Hector Neris struck out Max Kepler to end the threat.

Ryan Pressly shut the door on the Twins, striking out the side for his second save to preserve the Astros' 3–2 victory and win the series.